It’s a four-drug cocktail if you count ritonavir. My bad! I completely missed that "nuance" - and just for sake of comparison, I would guesstimate that SOC plus Ritonavir plus DAA get similar rates of efficacy? http://www.prnewswire.com/news-releases/intermune-reports-virologic-response-of-ritonavir-boosted-danoprevir-rg7227itmn-191-in-patients-with-chronic-hepatitis-c-90949624.html (Given that it contains SOC I would guess that the above protocol has typical rates of breakthrough etc)