Yikes. Are you going to hold them through any (theoretical to this point) run-up or, wait till after FDA decision? From what I can tell, most people are going to dump their shares after any (hypothetical) approval. So, most likely (with an FDA approval) there will be a mass exodus and share price drop within days of approval. On the other hand, if I was the CEO, I'd have several deals contingent on approval that would prevent that drop.