You never know which one is going to move get bought out, get a big deal or whatever first but what I did was try and setup my portfolio by considering potential %'s gains (the only thing that matters as opposed to PPS increase) & how soon I think a major catalyst will occur. For instance, I sold most of my THLD at avg. of $6.87 and bought IMUC at avg. of 2.06 because I think IMUC hits $4.12 (100% increase) before THLD hits $13.74. I also think CLSN hits $3.62 (avg. cost of $1.81) before THLD hits $13.74 etc. I have positions in 6 other stocks and I adjust my portfolio concentration using the same type of strategy (while retaining positions in all) and it's been working quite well.