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Re: mcbio post# 138623

Tuesday, 03/13/2012 6:11:48 PM

Tuesday, March 13, 2012 6:11:48 PM

Post# of 257253
Two questions

1- What % of women at FR++?

2- Curious what imbalances would have specifically caused such different results.

In addition, Endocyte today announced updated overall survival data from the PRECEDENT trial, which show improvement compared to the results announced in December 2011. Overall survival was a secondary endpoint in the PRECEDENT trial, but it was underpowered to demonstrate a definitive result in this endpoint. In particular, the overall survival hazard ratio for the FR(++) patient group was 1.097. Adjusting for prognostic imbalances between the study arms, the adjusted hazard ratio of 0.481 reflects a 52 percent reduction in the risk of death. Overall survival statistics in the intent-to-treat population were also slightly improved compared to those announced in December and those data will be presented at an upcoming medical conference.

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