Saw part of this presentation given by two KOL-type HCV docs. Most striking takeaway for me was their comment about how they are reducing the use of the 1st-generation PI drug combos because of the SAE's they have encountered. Seems like when you give this regimen to sicker patients than were enrolled in the trial, the SAEs (sounded like mainly anemia and gastric issues) become quite significant. Their main point was that the sicker patients have SAEs and the less-sick ones you can re-warehouse waiting for the newer drugs.
But they did say that the community docs will likely continue to use the PI's for now.
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