Biotech Values

[hirogen]

OK so he was referring to the total alpha of 0.025. Is that one-sided or two-sided?

At a conference prior to 1st interim announcement, Kirkman used the phrase to describe trial design as "at the .025 level". Back then I asked the same question on the IV board you are asking now. I got a succinct reply from Nono that it was 1 sided. I have not been able to confirm this independently. But I will say Nono has been a pretty reliable source of info on START.

Perhaps this is a German pharma thing. A Bayer presentation on regorafenib in last line mCRC (CORRECT trial) had a slide showing trial design with the statement "1 sided overall alpha = 0.025"