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Re: genisi post# 137354

Sunday, 02/19/2012 6:05:56 AM

Sunday, February 19, 2012 6:05:56 AM

Post# of 257302

Riba could be too weak in GT1




Right. The market may have been kind to GILD's stock on Friday considering the run-up since the deal was announced.




Either way, replacing Riba with a more potent DAA should help.




Purine nucleotides (using PSI-938 as an example) can be more potent than GS-7977. Since ribavirin's MoA is often compared to a weak purine nucleotide, do you feel this class could make up for the shortcomings of the GS-7977/Riba combination in nulls?

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