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biomaven0

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biomaven0

Re: genisi post# 137143

Thursday, 02/16/2012 1:29:54 PM

Thursday, February 16, 2012 1:29:54 PM

Post# of 252504
It's important to remember that crizotinib is not a particularly potent ALK inhibitor - it wasn't originally developed as one in the first place. So hopefully what we are seeing here in terms of resistance are the adverse consequences of using a weak inhibitor up front - the HIV space might provide an instructive analogy.

Peter
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