Tau pathology spread in AD The idea isn't new. One group showed evidence in-vitro and wrote: "We hypothesize that extracellular Tau aggregates can transmit a misfolded state from the outside to the inside of a cell, similar to prions." http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676015/?tool=pubmed And these groups showed the spread of tauopathy from cell to cell in the brains of tau transgenic mice by injecting brain samples in two mice strains: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726961/?tool=pubmed