FWIW, ISIS disclosed during their Analyst Day CC (Seeking Alpha has a transcript; http://seekingalpha.com/article/317739-isis-pharmaceuticals-ceo-hosts-analyst-day-transcript?source=yahoo ) today that they are dropping their PCSK9 candidate due to having lost their lead and, perhaps more importantly, due to safety questions/concerns from the FDA about the target. Sounds like very lengthy/expensive trials will be required against this target. I think this is what is alluded to in #msg-69444468 . Seems to be bearish for everyone targeting PCSK9 (REGN, ALNY, etc.) and not just ISIS.