Biotech Values

[genisi]

IMHO and FYI this is the most relevant publication for Alzheimer's

Bear in mind that the Genentech group work was done in developing peripheral embryonic mouse neurons, deprived of growth factor. At this point relevance of APP–DR6 to adult CNS tissue and to AD specifically, remains to be shown.

What I find compelling is that the mechanism, activation of death receptor 6, brings together all the known pieces of Alzheimer's pathology

There are many compelling observations to support their hypothesis and it does connect APP, BACE, and Swedish mutation, but has a few holes as well. Two missing pieces are how do p-Tau in the tangles and Aß in the plaques fit in the mechanism. This mechanism also cannot explain AD caused by other mutations in the presenilin genes or in the Aß site of APP. Btw, I don't believe any single mechanism will bring together all the pieces of AD.

a search of the patent filings indicates that they are still actively pursuing this target.

I would too No doubt this is just the begging.