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Sunday, December 11, 2011 4:31:35 PM
~ $AMBS ~ Apoptosis ~ Programmed Cell Death
http://www.amarantus.com/science/apopotosis.html
Apoptosis is the term used to describe Programmed Cell Death (PCD) in multicellular organisms. Apoptosis is one of the main types of PCD which involves a cascade of biochemical events leading to specific changes in the cell at the level of the nucleus, cytoplasm and plasma membrane, ultimately to cell death.
Apoptosis differs from necrosis, the other major type of cell death, in that the processes associated with apoptosis in disposal of cellular debris tend not to induce inflammation and further damage to the organism as a whole. Necrosis is a form of traumatic cell death that results from acute cellular injury. Apoptosis in contrast to necrosis, confers advantages during an organism’s life cycle. Since the 1990's research has increased substantially in the field of apoptosis. It has been shown that defective apoptotic processes in humans and animals are related to a variety of diseases. Excessive apoptosis has been implicated in neurodegenerative diseases like Parkinson’s and Alzheimer’s diseases, and diseases resulting from ischemic damage. Deficient apoptosis on the other hand can lead to uncontrolled cell proliferation, as occurs in cancer.
The development and careful application of therapies that mediate this biological pathway may lead to significantly improved patient outcomes in a verity of severe disorders.
http://www.amarantus.com/science/apopotosis.html
Apoptosis is the term used to describe Programmed Cell Death (PCD) in multicellular organisms. Apoptosis is one of the main types of PCD which involves a cascade of biochemical events leading to specific changes in the cell at the level of the nucleus, cytoplasm and plasma membrane, ultimately to cell death.
Apoptosis differs from necrosis, the other major type of cell death, in that the processes associated with apoptosis in disposal of cellular debris tend not to induce inflammation and further damage to the organism as a whole. Necrosis is a form of traumatic cell death that results from acute cellular injury. Apoptosis in contrast to necrosis, confers advantages during an organism’s life cycle. Since the 1990's research has increased substantially in the field of apoptosis. It has been shown that defective apoptotic processes in humans and animals are related to a variety of diseases. Excessive apoptosis has been implicated in neurodegenerative diseases like Parkinson’s and Alzheimer’s diseases, and diseases resulting from ischemic damage. Deficient apoptosis on the other hand can lead to uncontrolled cell proliferation, as occurs in cancer.
The development and careful application of therapies that mediate this biological pathway may lead to significantly improved patient outcomes in a verity of severe disorders.
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