I do not agree with your implicit assumption in #msg-69361018 that the addressable market for substitutable FoB’s is merely what is left over after non-substitutable FoB’s are deducted from the total market for off-patent biologics. Rather, substitutable FoB’s also have an opportunity to claim a portion of the addressable market for non-substitutable FoB’s (which I estimated at 35-40% of the pie in #msg-69358423).
Proviso: To take advantage of the above, development programs for substitutable FoB have to be started early—i.e. they have to be well into the research phase even now.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”