The mice abstract might provide some clues as to what the drug is doing: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=df62cef8-2afd-4abd-a333-e99c6424260e&cKey=73aa0e2e-5c02-4e7e-8a15-1ab1c7468fc5&mKey=%7bA57FF86D-D414-4079-BCBD-157746574F37%7d Notice the biphasic dose response in osteoblasts. That might complicate figuring out exactly what the drug does in humans some. Peter