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Re: mcbio post# 130014

Wednesday, 11/02/2011 3:58:00 AM

Wednesday, November 02, 2011 3:58:00 AM

Post# of 257262

Management noted that in a recent Roche trial, DTIC showed overall survival in BRAF melanoma patients of about 8 months. The Phase 2 combo selumetinib trial in BRAF melanoma patients has still not reached the pre-specified number of events and top-line results are now not expected until 1H2012. (The trial completed enrollment over 18 months ago.)



oh well, i'll try not to get too excited about that. a couple more things that i liked and are new to me:

slide 11, potential size of KRAS mutant NSCLC market: 1 billion (thought it was much smaller)
slide 10, selumetinib royalty: potential double-digits (since it's such an old collaboration and they had never mentioned it, i had assumed it was single-digits)

big believer in ARRY and mostly in their MEK inhibitors used in combination. mcbio: thanks for all the useful information.

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