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Re: md1225 post# 129018

Sunday, 10/23/2011 10:07:32 AM

Sunday, October 23, 2011 10:07:32 AM

Post# of 253249
Not that I have something against iBio's plant production system, quite the contrary, but once again (first time was when a paid promoter of iBio posted that the iBio has a more versatile technology than Protalix does), I would like to comment on a careless sentence:

PLX is 20 years in the past

Perhaps when stating this you were referring to the first plant-derived human recombinant protein expressed in transgenic plants (Sijmons et al., 1990; Production of correctly processed human serum albumin in transgenic plants). Since then, progress has been made in many aspects and current players moved into different directions according to their unique systems. PLX's novelty is its cell suspension grown in disposable plastic bioreactors. iBio's novelty is its agroviral vector. Although these companies use different plant production systems, delivery methods etc., both basic technologies (stable expression of transgenes in plant cell lines and transient expression of transgenes in plants using virus-based system and delivery via Agrobacterium) are just about the same age. There were and still are few players such as Large Scale Biology Corp that developed lymphoma vaccine using plant transient expression systems back in the 90's and Icon Genetics used a similar tech (with a better vector, imo).


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