Biotech Values

[jq1234]

It was unclear to me how they counted patients that died in that period (or deteriorated enough so that they were never treated).

It's always murky to compare single arm trial vs historical control.

In a randomized trial those patients would of course be part of the drug group, but in a comparison with historical controls they might not have been so fastidious.

Not necessarily, for CDX110 latest trial, patients started chemoradiation immedidately after surgery, for about 3 months, then starts vaccine. In randomized trial, randomization could start here after lead in period, whether they get CDX110 vaccine or placebo. Those patients you talked about wouldn't be in either arm.