Even the science is complicated, as one can find out by exploring androgen dependent and androgen independent states. Of course this relates to the treatment strategies as well. Throw in the issue of metastasis, it is no wonder that the urologists and the oncs have some (or a lot) of difficulties here.
I used to work on the enzyme that converts T to DHT so I have some hands on knowledge of at least some of the science. Always learning here.
Thanks for providing your multiple perspectives on the DNDN issues including the " high density" statement.