If the randomization was “properly performed” and baseline MRI status was a pre-specified variable of interest, why weren’t the trial arms stratified with respect to this variable?
I'm assuming they didn't stratify with respect to all possible variables.
It's worth noting that Avonex also didn't beat placebo in the non-adjusted comparison, but did so after adjustment.
The interesting play here might be the Swedish company Active Biotech (NASDAQ OMX NORDIC: ACTI) which was down very sharply indeed.