Quote: Is there any concern about the effect of TPO agonists on cancer progression and/or survival, as there is with the ESAs? Excellent question. Since I had to look this up, thought I would share the link: http://www.medscape.com/viewarticle/717033 So it looks like the ESA issue only was identified from a meta analysis after the fact? I am not clear on the details/design of the promacta cancer trials to know if such an issue would likely be identified