NVS’ QAB149 (Onbrez) approved in Japan at 150mcg dose: http://www.novartis.com/newsroom/media-releases/en/2011/1527927.shtml The importance of the QAB149 150mcg dose for the QVA149 combination product is discussed in the prologue of #msg-64761738. QAB149 monotherapy is now approved in every major country (more than 60 countries in all) except the US, where the PDUFA date is today.