1:43AM Alexion Pharma presents new data show renal impairment is strong predictor of early death in patients with PNH (ALXN) 45.52 : Co announces research that provides further insight into the clinical consequences of paroxysmal nocturnal hemoglobinuria, and positive impact of Soliris therapy on long-term outcomes. The study found that patients with PNH who have late-stage renal impairment had a significantly worse overall survival rate compared with PNH patients without renal impairment. Researchers analyzed data from 301 patients enrolled in the National Data Registry in South Korea to assess the impact of late-stage renal impairment in patients with PNH: 16% of patients had a history or presence of late-stage renal impairment, and these patients accounted for 35% of patient deaths in the registry. Patients with late-stage renal impairment had significantly worse overall survival compared with PNH patients with no impairment. A multivariate regression analysis showed that renal impairment was a strong predictor of mortality.
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