Thursday, June 09, 2011 11:33:40 PM
Might not be what you think. IMHO what we got Wednesday was a backup filler for what was intended to be a lot more significant news but something wasn't quite ready for it yet.
Because of the PR on Dr Kaplan's appointment I suspect that that something was confirmation of a process for separation of spider silk protein and worm silk protein and that the problem was due to the two proteins sticking together.
Both proteins are bound to have powerful self sticking properties in order for them to form strong silk fibers. Because of their similarity it seems quite possible that they stick to each other as well.
But there is a ready answer: something in spiders and worms keeps the proteins from sticking to each other until they reach the spinarettes. So use that or some close biochemical equivalent to dissolve the cocoons and keep the proteins separate instead of whatever solvent they were using and keep them in that solvent until the separation has been accomplished.
The above is NOT meant so much to be an indication of exactly what happened as it is an indication of the types of relatively minor problems and setbacks that can arise and how they get worked around.
That kind of thing happens more often than not in biology and biotechnology. The public never hears about it, but it's what's responsible for a great deal of the uncertainty of progess in research. Major problems also occur but less frequently. The minor ones are an almost day to day thing.
IMHO. When you are dealing with research of this nature it is highly unrealistic to expect things to always happen on schedule and those who get unduly unset when it doesn't probably won't have much success investing in this area, IMHO.
Also remember that the spider silk protein from Monster Hybrid cocoons was just a way to get pure spider silk protein on the market a little bit sooner. It it turned out to be too difficult to separate the worm from the spider silk protein then it wouldn't make sense to waste too uch time on it because the pure spider silk producing worms will be available soon anyway.
Because of the PR on Dr Kaplan's appointment I suspect that that something was confirmation of a process for separation of spider silk protein and worm silk protein and that the problem was due to the two proteins sticking together.
Both proteins are bound to have powerful self sticking properties in order for them to form strong silk fibers. Because of their similarity it seems quite possible that they stick to each other as well.
But there is a ready answer: something in spiders and worms keeps the proteins from sticking to each other until they reach the spinarettes. So use that or some close biochemical equivalent to dissolve the cocoons and keep the proteins separate instead of whatever solvent they were using and keep them in that solvent until the separation has been accomplished.
The above is NOT meant so much to be an indication of exactly what happened as it is an indication of the types of relatively minor problems and setbacks that can arise and how they get worked around.
That kind of thing happens more often than not in biology and biotechnology. The public never hears about it, but it's what's responsible for a great deal of the uncertainty of progess in research. Major problems also occur but less frequently. The minor ones are an almost day to day thing.
IMHO. When you are dealing with research of this nature it is highly unrealistic to expect things to always happen on schedule and those who get unduly unset when it doesn't probably won't have much success investing in this area, IMHO.
Also remember that the spider silk protein from Monster Hybrid cocoons was just a way to get pure spider silk protein on the market a little bit sooner. It it turned out to be too difficult to separate the worm from the spider silk protein then it wouldn't make sense to waste too uch time on it because the pure spider silk producing worms will be available soon anyway.
Recent KBLB News
- Kraig Biocraft Laboratories Smashes Production Targets as New Spider Silk Batch Surges Past Expectations • GlobeNewswire Inc. • 05/26/2026 11:35:00 AM
- Form 424B3 - Prospectus [Rule 424(b)(3)] • Edgar (US Regulatory) • 05/22/2026 08:30:20 PM
- Form 424B3 - Prospectus [Rule 424(b)(3)] • Edgar (US Regulatory) • 05/22/2026 08:30:19 PM
- Kraig Biocraft Laboratories Highlights Technical Breakthrough of Its Immortalized Silk Gland Cell Platform • GlobeNewswire Inc. • 05/20/2026 11:35:00 AM
- Immortalized Silk Gland Cell Line Breakthrough Expands Kraig Biocraft’s Biotech Ambitions (KBLB) • IH Market News • 05/18/2026 03:12:33 PM
- Kraig Biocraft Laboratories Announces Breakthrough Creation of Immortalized Silkworm Silk Gland Cell Line with Broad Biotechnology Applications • GlobeNewswire Inc. • 05/18/2026 11:05:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/14/2026 08:31:50 PM
- Form 424B3 - Prospectus [Rule 424(b)(3)] • Edgar (US Regulatory) • 05/14/2026 12:14:08 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 05/14/2026 04:15:05 AM
- The Plastic Crisis Is Exploding and Kraig Biocraft Laboratories Has a Unique Answer • GlobeNewswire Inc. • 05/13/2026 01:05:00 PM
- Form POS AM - Post-Effective amendments for registration statement • Edgar (US Regulatory) • 05/11/2026 08:30:47 PM
- Kraig Biocraft Laboratories Commissions New Production Rearing Center to Support Accelerating Spider Silk Scale-Up • GlobeNewswire Inc. • 05/11/2026 11:05:00 AM
- Kraig Biocraft Laboratories Positions Itself as a Front-Runner in Spider Silk Race • GlobeNewswire Inc. • 05/07/2026 01:05:00 PM
- Kraig Biocraft Laboratories Launches April/May Production Cycle Following Record Spider Silk Output • GlobeNewswire Inc. • 05/04/2026 11:05:00 AM
- Form 424B3 - Prospectus [Rule 424(b)(3)] • Edgar (US Regulatory) • 04/30/2026 09:07:15 PM
- Kraig Biocraft (KBLB) Spider Silk Production Milestone Signals Progress Toward Commercialization • IH Market News • 04/30/2026 02:54:26 PM
- Kraig Labs Clears Dual Commercialization Milestones with Record Spider Silk Production and Successful Reeling Operations • GlobeNewswire Inc. • 04/30/2026 01:20:00 PM
- Kraig Biocraft (USOTC:KBLB) Hits 50% Production Milestone — Spider Silk Push Moves Closer to Commercial Scale • IH Market News • 04/28/2026 01:51:39 PM
- Kraig Biocraft Laboratories Reports Major Progress Converting Record-Setting Spider Silk Cocoon Production into Reeled Silk • GlobeNewswire Inc. • 04/28/2026 11:05:00 AM
- Form POS AM - Post-Effective amendments for registration statement • Edgar (US Regulatory) • 04/21/2026 06:41:52 PM
- Kraig Biocraft Laboratories Advances Record Production and Begins Processing 1.8 Metric Tons of Recombinant Spider Silk Cocoons • GlobeNewswire Inc. • 04/20/2026 11:05:00 AM
- The End of Performance at Any Cost, as Spider Silk Points to a Cleaner Future • GlobeNewswire Inc. • 04/15/2026 01:15:00 PM
