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Re: NP1986 post# 121229

Tuesday, 06/07/2011 9:15:58 PM

Tuesday, June 07, 2011 9:15:58 PM

Post# of 257257

but it I'm not convinced that a drug that targets only ALK will be efficacious in the clinic



Based on my understanding of the pathway, if it's a tumor caused by an ALK rearrangement, then inhibiting ALK is all you need. Along the same lines as BCR/ABL in CML.

Pona of course currently has a much higher risk-adjusted NPV than does '113, but '113 in my view has greater ultimate potential.

Peter

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