Biotech Values

[investorgold2002]

JELIS - what do people think

Nobody clearly understands the various reasons for CV...there are tons of hypotheses

But let's talk about JELIS and CV outcomes. JELIS was statin+EPADEL/AMR101 vs statin

Primary Prevention - major coronary events - RR 19% P=0.011
Secondary Prevention -- major coronary events -RR 23% P=0.017
Prior MI 27% P=0.033
Prior Stroke 20% P=0.047
Prior MI or Intervention 41% P=0.008

Sub-group with Atherogenic Dyslipidemia (>150mg/dl and HDL < 40 mg/dl) 53% P=0.043

JELIS total cohort was very low heart risk
"Low Heart Risk Japanese population
Total cholesterol, mean (SD), mg/dl 270
LDL-cholesterol, mean (SD), mg/dl 178
HDL-cholesterol, mean (SD), mg/dl 55
Triglyceride, median (IQR), mg/dl 163"