>Enemy action But there is the confounding Arbiter 6-HALTS trial where Niaspan plus statin was shown to be superior (based on CIMT) to Zetia plus statin. http://content.onlinejacc.org/cgi/content/full/j.jacc.2010.03.017v1 Maybe carotid intima-media thickness isn't in fact a good endpoint or maybe Zetia actually did harm. Peter