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Re: DewDiligence post# 120292

Thursday, 05/19/2011 5:48:53 PM

Thursday, May 19, 2011 5:48:53 PM

Post# of 257257

Is my reading of Ablynx’s PR in #msg-63230818 unduly skeptical?



Maybe - after all this is going to be Pfizer's call, so Ablynx likely couldn't say anything more positive than they did. On the other hand, the mention of commercial prospects might be a signal - it's not as if they needed to mention that. So could be preparing the ground for why this program won't be taken forward.

Also on the bearish side, they only got significance at the highest dose tested, this is already a very crowded space and I don't see why nanobodies would be advantageous in this particular application. (As I understand it, they are smaller than traditional antibodies, which might help in something like an anti-tumor application, but here the TNF is circulating).

Peter

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