Could you summarize the efficacy seen in the oral calcitonin trials to date, or provide links to these? The issue for CT has been the peptide synthetic approach to the carboxy terminal amidation. This at least in the past has been required for biological activity. There are also amidases that cleave this moiety, even in the gut. This could be a big winner with good efficacy and a reasonable cost of goods. I believe it could be disease modifying for OP at least.