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Re: biomaven0 post# 119743

Tuesday, 05/10/2011 9:59:34 AM

Tuesday, May 10, 2011 9:59:34 AM

Post# of 257257
I'd add that inhibiting FLT3 in multiple trials has not to date lived up to expectations - partly it seems that levels of the FLT3 ligand increase, and this interferes with the inhibition.

It is possible that a very potent FLT3 inhibitor might work much better, so it certainly will be worth exploring whether pona has a role here. But the Ambit drug seems very potent as well.

Peter

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