Biotech Values

[biomaven0]

>>protamine

Unless you give it rapidly the minor complication rate is very small. (Transient drop in blood pressure).

From a recent Cochrane review:

Although being a relatively safe drug, it can cause severe systemic reactions with
pronounced morbidity and mortality [1], and protamine
sulfate is reported as one of the most common causes of
life-threatening adverse reactions during cardiac surgery
when used for rapid neutralization of heparin. Anaphylactic
reactions to protamine sulfate have been known for many
years, but the incidence reported varies from 0.06% to
10.6% [2] and range from minor haemodynamic instability
to fatal cardiovascular collapse. The incidence of catastrophic
reactions to protamine sulfate during cardiovascular surgery
is reported to be 0.13% [3], and a recent study has con-
?rmed the relation between protamine sulfate reactions and
mortality risk [4].

Reactions seem more common with diabetics that have received protamine-containing insulin, so maybe the current incidence is lower.

Peter