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Wednesday, May 04, 2005 3:20:40 PM
Re: RNVS
>>So, my take is that the Rankin Scale likely reflects real-life functional status, but is more subjective and less reproducible. The NIHSS seems to be a tool devised for studying strokes. I don't know how well either is validated, but strongly suspect that even the honchos don't know because they allowed both scales to be primary endpoints.<<
I concur with your last sentence. When it doubt, make them co-primary endpoints
Both of them are subjective endpoints, anyhow.
p.s. +100% today does seem overdone, but I do not follow this company closely.
>>So, my take is that the Rankin Scale likely reflects real-life functional status, but is more subjective and less reproducible. The NIHSS seems to be a tool devised for studying strokes. I don't know how well either is validated, but strongly suspect that even the honchos don't know because they allowed both scales to be primary endpoints.<<
I concur with your last sentence. When it doubt, make them co-primary endpoints
Both of them are subjective endpoints, anyhow. p.s. +100% today does seem overdone, but I do not follow this company closely.
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