Biotech Values

[dewophile]

the next gen are definitely more potent, but i was referring specifically to rate of conversion of RVR to SVR, so the group who seemingly had adequate potency on RG7128
now ti could be that knocking down virus even faster than 4 weeks - say undetectable at 1-2 weeks - will equate to SVR at a higher rate than undetectable at 4 weeks so your point is well taken
certainly there will be more RVRs on the newer nukes, but lets say the conversion to SVR is similar and you get 1005 RVR with combo - so 76% of pts with RVR get to SVR so efficacy is 76%. what regimen would you go on - one that added SOC for say 24 weeks that had a 90% SVR or an all oral that had 75%? of course it's more complicated than that since VRUs is cleverly testing shortened durations of interferon so it may be 76% without soc and another 10%+ with 4-12 weeks of interferon and rib. and how does that change if the interferon is lambda which is more tolerable?
jsut random thoughts as i think this through..