When you get such speed and efficacy in a dual nuke combo why experiment with other classes which will only reduce the resistance profile of a two drug combination.
Adding a third drug—even a bad one—cannot weaken the resistance profile of the first two drugs. What a third drug could do is add toxicity, but that’s another matter entirely.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”