In the US, Cinryze was approved for prophylaxis in Oct 2008 (#msg-32795311); however, Cinryze for the acute indication is blocked by CSL’s Berinert, which has marketing exclusivity until 2016 stemming from an orphan designation and FDA approval in Oct 2009 (#msg-42409618).
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”