Biotech Values

[dewophile]

but I think a cocktail of three oral drugs will likely be needed to generate the kind of SVR rate capable of supplanting the current SoC of interferon and ribavirin

the best chance for a 2 drug cocktail is a combination of nukes since they each have higher barriers to resistance. i'm not sure for these particular nukes what mutation(s) are necessary to confer resistance, but if you need more than one mutation for example for resistance to an agent it almost as if it is equivalent to giving 2 (or more) drugs. for example baraclude if memory serves me right requires three mutations for resistance - that one drug is in effect almost like multitherapy in terms of resistance