ORAL-Sync, the second phase-3 trial of Tofacitinib in RA, tested DMARD ± Tofacitinib in the second-line setting. The first phase-3 trial, ORAL-Solo, tested Tofacitinib as monotherapy in the second-line setting and hit its primary endpoint in Nov 2010 (#msg-56398000).
Tofacitinib is shaping up to be the most consequential drug in PFE’s pipeline.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”