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Re: mcbio post# 115538

Saturday, 02/26/2011 1:19:30 PM

Saturday, February 26, 2011 1:19:30 PM

Post# of 257264

"One patient developed non-neutralizing IgG antibodies to taliglucerase at the end of the study." I don't know exactly what this means and if this is something to potentially be concerned about. What are your thoughts on this?



That's to be expected when foreign enzyme is injected. The expected rate of developing IgG antibody from Cerezyme is 15%, roughly half of those patients had hypersensitivity symptom.

Here is Cerezyme safety information:

http://www.cerezyme.com/healthcare/safety/cz_hc_safety.asp

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