In addition to the program risk stemming from the novel MoA, there is some execution risk in the melanoma setting stemming from the unusual primary endpoint of the phase-3 trial:
Primary Outcome Measure: Achieving a statistically significant improvement in durable response rate, defined as the rate of CR or PR lasting continuously for 6 or more months, as compared to control therapy.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”