I would not rule out a finding of non-inferiority based on those numbers. As you know, the experimental drug in a non-inferiority analysis can be numerically worse than the comparator and still be deemed statsig non-inferior if the “bad” boundary of the confidence interval on the difference is not worse than a prespecified delta.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”
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