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Re: turtlepower post# 110103

Sunday, 12/05/2010 3:04:52 PM

Sunday, December 05, 2010 3:04:52 PM

Post# of 257302

My understanding is that the response rate normally only includes complete + partial responses so in this case it would be 2/30. IMO even if ARRY-520 is a single agent the response rate should be comparable to combinational treatments.

ARRY is conducting a single agent PII trial so they must see something positive
.

I would think that SD for >6 months for 26% of these highly refractory MM patients means something clinically. Perhaps that's why ARRY is moving forward into Phase 2 in testing 520 as a single-agent. It's either that or Zebra's Law for the single-agent aspect of the drug. I'm anxious to see results for the combo of 520+Velcade as management seems to be touting more potential for 520 in combination with Velcade as opposed to just a single-agent.

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