I’ll bet there have been cases where shares have been sold to unsuspecting investors based on interim (high-biased) RR data from the randomized portion of an RDT.
I personally can't think of such a case. It's not like RDTs are that common.
Here's a good free full-text article setting out the case for RDTs:
The randomized discontinuation trial: a phase II design to assess growth-inhibitory agents