While I'm not up to date I could find the following in just five minutes.. so, there are many involved... that should not be a surprise: http://www.triroc.com/sunnen/topics/ozonemed.htm http://www.healingcancernaturally.com/medical-ozone-fda.html http://www.consumerhealth.org/articles/display.cfm?ID=19990303183533 http://ozonetherapy.org/ http://www.oxidation-therapy.com/pages/information/research.html