NVS’ DEB025, a cyclophilin inhibitor for HCV, can potentially work as monotherapy or in combination with other HCV drugs. DEB025 does not lead to rapid resistance when given as monotherapy because it blocks a host protein rather than a viral protein. Below are 50-day data for DEB025 dosed for 28 days as monotherapy or in combination with Pegasys without ribavirin. Genotype-1/4 data are on the left and genotype-2/3 data are on the right. (‘LQ’ = level of quantitation.)