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Re: ghmm post# 108637

Wednesday, 11/10/2010 3:23:57 PM

Wednesday, November 10, 2010 3:23:57 PM

Post# of 257262

Not sure patients would agree but from a clinician standpoint I would think even a 5% delta [SVR] would warrant the additional drug(s). Thoughts anyone?

Provided that you’re calculating SVR on an ITT basis (so the SVR number incorporates the effect of premature discontinuations), I concur that a 5% SVR delta warrants adding a drug to the cocktail. In the case of ribavirin, specifically, the cost delta is not a major concern insofar as ribavirin is available as a generic.

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