The links may require a membership (but its free) to view.
http://www.nature.com/nrd/journal/v9/n11/pdf/nrd3316.pdf http://www.nature.com/nrd/journal/v9/n11/full/nrd3316.html Here is a nice article about protein misfolding. I was unaware of the Roche deal they mention and (not surprisingly) big Pharama have their own internal programs here. I think the science sounds intreging and the molecules (at least Amicus's) were extremly small and simple in structure. Hopefully this could lead to breakthroughs in many diseases especially since areas like Alzheimers could benefit from new approaches IMO.