i think it crazy vvus get a rejection from fda even though their maybe potential for the drug to get approval down the line(ya right the drug exist as phenteramine(Adipex-P(weight loss} and topiramate(seizure drug primary indication and secondary mirgrane proohylaxis) As a pharmacist i know how topiramte must be monitored routinely because of the bucketlist of side effects. This drug does not get approved ever just my opinion why approve a drug that already exist on the market