"Why were the Phase 3 trials in everolimus and temsirolimus stopped then, at the interim? "
Do you mean the RAD001 trial, it was well more than just stat sig:
"The primary endpoint of progression-free survival was increased from median 1.9 to 4.9 months (hazard ratio 0.33, P < 0.001) "
Then why did The Harv say (several times I might add), that based on the way the "trial is powered, there is a reasonable chance" it would be stopped at the 2nd Interim