Biotech Values

[biomaven0]

I don't have access to the published article, so I was going from their PR:

In both PREEMPT studies, patients treated with BOTOX® experienced a significantly greater decrease in the frequency of headache days from baseline compared to patients treated with placebo at the week 24 primary endpoint (7.8 and 9.2 fewer days for the BOTOX® group, versus 6.4 and 6.9 days for the placebo group, respectively). Also at week 24, patients treated with BOTOX® experienced a total cumulative reduction in headache hours by 107 and 134 hours, respectively, compared to 70 and 95 hours, respectively, in patients treated with placebo.

Their first sentence is ambiguous as to whether they meant over the whole period or over the last month, but if you look at the reduction in hours - 107 vs 70, that is certainly cumulative and is 4.5 days total vs. 2.9 days worth over the cumulative 24 week period. So my point about clinical significance is still valid - basically 1.5 days less pain over a 24 week period.

Now that I think more about it though, your interpretation of the endpoint certainly makes more sense than mine - I'll have to try to get access to the actual paper to confirm.

Peter