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genisi

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genisi

Re: jellybean post# 106400

Sunday, 10/17/2010 7:29:42 AM

Sunday, October 17, 2010 7:29:42 AM

Post# of 252273

...linked by disulfide bonds

The linker component of T-DM1 is SMCC, which uses a stable thioether bond and is therefore a non-cleavable linker (that needs to be internalized in the cell where the antibody is degraded and the active drug becomes available), while disulfide bonds are cleavable.

Ref:IMGN AACR abs # 4398

http://www.immunogen.com/pdf/AACR%204-10%20poster%20of%20abst%204398.pdf
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