Biotech Values

[rkcrules2001]

Question for Winchem

My prior statement about "even 10mg squalamine blowing away" Macugen is not really correct. I kept thinking about the published 10mg N=6 average at EOT of -.8, versus the +2.7 you calculated when the high and low results are thrown out. This led me to attempt to reproduce your calculations, and I came up with some differences. In particular, the +2.7 10mg EOT number changed to +.3. That's still better than Macugen's apparent average of -.7, but it's not realy "blowing away".

Below are the numbers I came up with, but again I'm not certain my formulas are correct. Would you please reassess your adjusted 10mg EOT number, and see if you get +2.7 or +.3? Am I doing something wrong?

Here are my numbers....

Date       Mex  40mgst   40mg2nd  10mg 
 Wk3        6.3   6.9       4.3     0.8 
 EOT        8.6   7.8       7.1     0.3 
 2Mon       6.7   2.8       3.3    -2.0 
 4Mon       5.5  -2.0       4.0    -2.7

These numbers would produce a revised average 40mg 2Mon-to-4Mon dropoff of 1.0 letter per month (versus the .83 in my earlier post), which is exactly what you said originally. A monthly loss of 1.0 letters is still better than the 1.2 average loss for folks going without any treatment, but it is even more hair-splitting, especially considering the low Ns.

Just for ref, here are your original numbers...

Date  Mex  40mgst 40mg2nd 10mg 
 Wk3   6.5   6.9     4.3	   0.8 
 EOT   8.8   7.8     7.1    2.7 
 2Mon  6.9   2.8     2.9   -1.9  
 4Mon  5.7  -1.5     3.9   -2.0